4-quinolinyl derivatives

US5589484A · kind A · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Marc Gaston Venet · Sotteville-lès-Rouen, FR
• J er ome E. G. Guillemont · Oissel, FR
• Daniel F. J. Vernier · Val-de-Reuil, FR
• Frank Christopher Odds · Schilde, BE

Key dates

• Filing date: Apr 4, 1995
• Grant date: Dec 31, 1996
• Expiry date: Apr 4, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is concerned with novel quinoline derivatives having anti-Helicobacter activity of formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, the stereochemically isomeric forms thereof, the quaternized forms thereof and the N-oxides thereof, wherein --A-- represents a bivalent radical of formula EQU --N.dbd.CH--CH.dbd.CH-- (a), EQU --CH.dbd.N--CH.dbd.CH-- (b), EQU --N.dbd.N--CH.dbd.CH-- (c), EQU --N.dbd.CH--N.dbd.CH-- (d), EQU --N.dbd.CH--CH.dbd.N-- (e), EQU --CH.dbd.N--N.dbd.CH-- (f), EQU --N.dbd.N--N.dbd.CH-- (g), EQU --N.dbd.N--CH.dbd.N-- (h), or EQU --CH.dbd.CH--CH.dbd.CH-- (i); PA1 R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each independently represent hydrogen, halo, hydroxy, C.sub.1-4 alkyloxy, C.sub.1-4 alkyl, trifluoromethyl, amino, mono- or di(C.sub.1-4 alkyl)amino or nitro, provided that when one substituent on a phenyl group is a nitro then the other substituents on said phenyl group are other than nitro; novel compositions comprising said compounds, processes of preparing said compounds and compositions and methods for treating subjects suffering from disorders or afflictions associated with Helicobacter i…