Benzimidazoles useful as angiotensin-11 antagonists

US5591762A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Norbert Hauel · Schemmerhofen, DE
• Berthold Narr · Biberach, DE
• Uwe Ries · Biberach an der Riß, DE
• Jacobus Van Meel · Biberach, DE
• Wolfgang Wienen · Äpfingen, DE
• Michael Entzeroth · Warthausen, DE

Key dates

• Filing date: Jun 1, 1995
• Grant date: Jan 7, 1997
• Expiry date: Jun 1, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are angiotensin-II antagonists of the formula ##STR1## wherein R.sub.1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R.sub.2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R.sub.3 is, inter alia, lower alkyl; and, R.sub.4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: PA1 (a) 4'-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)-benzimidazol-1-yl] methyl]-biphenyl-2-carboxylic acid.