Triazolo(pyrrolo, thieno or furano)azepine derivatives

US5595988A · kind A · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Frans Eduard Janssens · Bonheiden, BE
• Jean Fernand Armand Lacrampe · Le Mesnil-Esnard, FR
• Isabelle Noëlle Constance Pilatte · Louviers, FR

Key dates

• Filing date: May 8, 1995
• Grant date: Jan 21, 1997
• Expiry date: May 8, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antiallergic triazolo(pyrrolo, thieno or furano)azepines of formula ##STR1## the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein PA0 each of the dotted lines independently represents an optional bond; PA0 -E-G- is a bivalent radical of formula EQU --X--C(R.sup.1).dbd.CH-- (a-1); or EQU --CH.dbd.C(R.sup.2)--X-- (a-2); PA0 X represents O, S or NR.sup.3 ; PA0 R.sup.3 represents hydrogen, C.sub.1-6 alkyl or C.sub.1-4 alkylcarbonyl; PA0 -B.dbd.D- is a bivalent radical of formula EQU --C(R.sup.4).dbd.N-- (b-1); or EQU --N.dbd.C(R.sup.5)-- (b-2); PA0 L represents hydrogen; C.sub.1-6 alkyl; substituted C.sub.1-6 alkyl; C.sub.3-6 alkenyl; C.sub.3-6 alkenyl substituted with aryl; or, PA0 L represents a radical of formula -Alk-Y-Het.sup.1 (c-1), -Alk-NH--CO-Het.sup.2 (c-2) or -Alk-Het.sup.3 (c-3). Compositions comprising said compounds, processes of preparing the same and intermediates in the preparation thereof.