Modified internucleoside linkages having one nitrogen and two carbon atoms
US5596086A · kind A · utility
543Cited by
3References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 20, 1991 |
| Grant date | Jan 21, 1997 |
| Priority date | — |
| Expiry date | Sep 20, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Oligonucleotide analogs are disclosed wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by a backbone linkage resistant to nucleases. The modified oligonucleotides are capable of strong hybridization to target RNA or DNA. The oligomers of the invention may be used as diagnostic reagents to detect the presence or absence of the target DNA or RNA sequences to which they bind.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.