Tumor necrosis factor muteins
US5597899A · kind A · utility
25Cited by
4References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 24, 1994 |
| Grant date | Jan 28, 1997 |
| Priority date | — |
| Expiry date | Mar 24, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Human TNF muteins having higher binding affinity for human p75-TNF receptor than for human p55-TNF receptor include muteins having at least one different amino acid relative to wild-type human TNF at a position corresponding to position 33, 65, 67, 75, 87, 143, 145 or 147 of the wild-type amino acid sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.