Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
US5597909A · kind A · utility
429Cited by
11References
26Claims
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Key dates
| Filing date | Aug 25, 1994 |
| Grant date | Jan 28, 1997 |
| Priority date | — |
| Expiry date | Aug 25, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/6823
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods and reagents are provided for synthesizing polynucleotides containing modified deoxyribose residues. Monomeric reagents having the structural formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined herein, are used to create polynucleotides having nonnucleotidic moieties -A-Z-(R.sup.9).sub.n at the 1 position of selected deoxyribose units. The polynucleotides so provided are useful in a variety of hybridization assay formats.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.