Antiviral composition

US5599839A · kind A · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• BRIGHAM YOUNG UNIVERSITY · US

Inventors

• Michael R. Boyd · Mobile, US
• Paul Alan Cox · Bristol, GB
• Gordon M. Cragg · Bethesda, US
• Peter M. Blumberg · Frederick, US
• Nancy A. Sharkey · Rockville, US
• Junichi Ishitoya · Bethesda, US
• James B. McMahon · Frederick, US
• John A. Beutler · Braddock, US
• Owen S. Weislow · Reston, US
• John H. Cardellina, II · Fort Detrick, US
• Krik R. Gustafson · Wheaton, US

Key dates

• Filing date: Apr 17, 1995
• Grant date: Feb 4, 1997
• Expiry date: Apr 17, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to an antiviral composition and to methods of treating patients with viral infections. The antiviral composition of the present invention comprises prostratin, a phorbol ester derivative, and a pharmaceutically acceptable carrier. The present composition while having antiviral activity does not have substantial tumor promoting activity and does not have other substantial adverse toxicological properties that would preclude its use in antiviral therapy.