Backbone modified oligonucleotide analogs
US5602240A · kind A · utility
921Cited by
8References
20Claims
0Family size
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Key dates
| Filing date | Apr 25, 1994 |
| Grant date | Feb 11, 1997 |
| Priority date | — |
| Expiry date | Apr 25, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Oligonucleotide analogs are provided wherein phosphodiester inter-sugar linkages are replaced with four atom linking groups. Such linking groups include NR--C(O)--CH.sub.2 --CH.sub.2, NR--C(S)--CH.sub.2 --CH.sub.2, CH.sub.2 --NR--C(O)--CH.sub.2, CH.sub.2 --NR--C(S)--CH.sub.2, CH.sub.2 --CH.sub.2 --NR--C(O)--R--CH.sub.2, and CH.sub.2 --C(S)--NR--CH.sub.2. Methods for preparing and using these oligonucleotide analogs are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.