Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors

US5604251A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Holger Heitsch · Hofheim, DE
• Rainer Henning · Tokyo, JP
• Adalbert Wagner · Gersthofen, DE
• Hermann Gerhards · Hofheim, DE
• Reinhard Becker · Wiesbaden, DE
• Bernward Sch olkens · Kelkheim, DE

Key dates

• Filing date: Jun 7, 1995
• Grant date: Feb 18, 1997
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/90
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain, process for their preparation and their use Compounds of the formula (I) ##STR1## in which R.sup.1 is, for example, ethyl, PA1 R.sup.2 is, for example, methyl, PA1 n is, for example, zero, PA1 R.sup.3 is, for example, COOH, and PA1 R.sup.4 is, for example, SO.sub.2 NHCONHCH.sub.3 are highly active antagonists of angiotensin II receptors.