Benzazepinone derivatives

US5610153A · kind A · utility

Assignee

• Ciba-Geigy · US

Inventors

• Peter Buhlmayer · Arlesheim, CH
• Pascal Furet · Basel, CH

Key dates

• Filing date: Jul 12, 1994
• Grant date: Mar 11, 1997
• Expiry date: Jul 12, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D281/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to substituted 3-amino-1-arylalkyl-benzazepin-2-ones of the general formula ##STR1## wherein Ar is aryl; PA1 X is --O-- or --S(O).sub.n -- and n is 0, 1 or 2; PA1 X.sub.1 is C.sub.1 -C.sub.2 alkylene or a direct bond; PA1 R.sub.1 is hydrogen, lower alkyl, aryl-lower alkyl or acyl; PA1 R.sub.2 is lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, aryl-lower alkoxy-lower alkyl, aryl-lower alkyl or C.sub.3 -C.sub.7 cycloalkyl-lower alkyl; PA1 R.sub.3 is carboxy; lower alkoxycarbonyl; lower alkoxy-lower alkoxycarbonyl; aryl-lower alkoxycarbonyl; aryloxycarbonyl; carbamoyl; carbamoyl that (i) is monosubstituted by hydroxy, lower alkanesulfonyl, halo-lower alkanesulfonyl or by arylsulfonyl, (ii) is monosubstituted or disubstituted, the substituents being independent of one another, by lower alkyl, lower alkenyl, lower alkynyl or by phenyl-lower alkyl or (iii) is disubstituted by lower alkylene or by lower alkylene-Z.sub.1 -lower alkylene, Z.sub.1 being O, S or NH; 5-tetrazolyl; PO.sub.2 H.sub.2 ; PO.sub.3 H.sub.2 or SO.sub.3 H.sub.2 ; the ring A and aromatic radicals are, independently of one another, unsubstituted or mono- or poly-substituted by substituen…