Backbone modified oligonucleotide analogues

US5610289A · kind A · utility

Assignee

• Isis Pharmaceuticals, Inc. · US

Inventors

• Phillip Dan Cook · Carlsbad, US
• Yogesh S. Sanghvi · Encinitas, US
• Jean-Jacques Vasseur · Juvignac, FR
• Francoise Debart · Juvignac, FR

Key dates

• Filing date: Apr 7, 1994
• Grant date: Mar 11, 1997
• Expiry date: Apr 7, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Therapeutic oligonucleotide analogues which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligomers with four atom linking groups forms unique di- and poly- nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.