Apparatus and method for multiple simultaneous synthesis

US5612002A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Donna Reynolds Cody · Saline, US
• Sheila DeWitt · Auburn, US
• John C. Hodges · Ann Arbor, US
• John S. Kiely · San Diego, US
• Walter H. Moos · Ann Arbor, US
• Michael R. Pavia · Newton, US
• Bruce D. Roth · Ann Arbor, US
• Mel C. Schroeder · Dexter, US
• Charles J. Stankovic · Ann Arbor, US

Key dates

• Filing date: Apr 28, 1995
• Grant date: Mar 18, 1997
• Expiry date: Apr 28, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B60/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method for the multiple, simultaneous synthesis of compounds comprising the steps of: 1) providing an apparatus comprising a plurality of reaction tubes having filter members on their lower ends, a reservoir member for receiving the filter member, a holder member having a plurality of apertures for supporting the reaction tubes, and a manifold member adjacent to the holder member and enclosing the upper ends of the reaction tubes; 2) charging the apparatus with reactants required for synthesis; 3) synthesizing the compounds in solution; or optionally 4) cleaving the compounds from a solid support within the apparatus.