IL-13 receptor specific chimeric proteins and uses thereof

US5614191A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Raj K. Puri · Bethesda, US
• Waldemar Debinski · Winston-Salem, US
• Ira H. Pastan · Potomac, US
• Nicholas Obiri · Gaithersburg, US

Key dates

• Filing date: Mar 15, 1995
• Grant date: Mar 25, 1997
• Expiry date: Mar 15, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a method and compositions for specifically delivering an effector molecule to a tumor cell. The method involves providing a chimeric molecule that comprises an effector molecule attached to a targeting molecule that specifically binds an IL-13 receptor and contacting a tumor cell with the chimeric molecule.