Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
US5614617A · kind A · utility
547Cited by
5References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 18, 1993 |
| Grant date | Mar 25, 1997 |
| Priority date | — |
| Expiry date | Feb 18, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/143333
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Oligonucleotide analogs are provided having improved nuclease resistance. Modifications of selected nucleotides through substitutions on the pyrimidine ring are disclosed. Certain preferred embodiments comprise the inclusion of said modified nucleotides at a plurality of sites, especially at the 3' end of a selected oligonucleotide analog.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.