5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses
US5614622A · kind A · utility
64Cited by
2References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 24, 1995 |
| Grant date | Mar 25, 1997 |
| Priority date | — |
| Expiry date | Aug 24, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotide under more mild conditions than existing methods. The invention further provides a nucleoside base protective group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protective groups, as well as nucleoside synthons having such base protective groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.