Inventor · Lowell, MA, US

Dong Yu

67Patents
17h-index
25Co-inventors
84Inventor score

Filing activity: May 22, 1995 → Oct 18, 2023

Most-cited inventions

PatentTitleAreaCited byStatus
US7276489B2 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends Human Necessities 176 Expired
US5614622A 5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses Emerging Cross-Sectional Technologies 64 Expired
US5962674A Synthesis of oligonucleotides containing alkylphosphonate internucleoside linkages Emerging Cross-Sectional Technologies 60 Expired
US6140482A Primary phosphoramidate internucleoside linkages and oligonucleotides containing the same Chemistry; Metallurgy 58 Expired
US7812000B2 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends Human Necessities 57 Active
US8202850B2 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends Human Necessities 55 Active
US5955599A Process for making oligonucleotides containing o- and s- methylphosphotriester internucleoside linkages Chemistry; Metallurgy 52 Expired
US8431544B1 Compositions for inhibiting gene expression and uses thereof Chemistry; Metallurgy 45 Active
US7407944B2 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends Human Necessities 37 Expired
US7517862B2 Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends Human Necessities 37 Expired
US7470674B2 Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides Human Necessities 32 Active
US7262286B2 Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes Chemistry; Metallurgy 29 Expired
US7427405B2 Immunostimulatory oligonucleotide multimers Human Necessities 28 Expired
US8008267B2 Stabilized immunomodulatory oligonucleotides Chemistry; Metallurgy 23 Active
US7405285B2 Immunostimulatory oligonucleotide multimers Chemistry; Metallurgy 23 Active
US7354907B2 Short immunomodulatory oligonucleotides Human Necessities 22 Expired
US9453228B2 Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response Chemistry; Metallurgy 20 Active
US6531589B1 Base protecting groups and synthons for oligonucleotide synthesis Emerging Cross-Sectional Technologies 16 Expired
US7566702B2 Immunostimulatory oligonucleotide multimers Human Necessities 16 Expired
US7498425B2 Immunostimulatory oligonucleotide multimers Human Necessities 16 Active
US7498426B2 Immunostimulatory oligonucleotide multimers Human Necessities 16 Active
US7569554B2 Synergistic treatment of cancer using immunomers in conjunction with therapeutic agents Chemistry; Metallurgy 15 Expired
US8426375B2 Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response Emerging Cross-Sectional Technologies 14 Active
US7960362B2 Synthetic agonists of TLR9 Human Necessities 14 Active
US8377898B2 Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response Chemistry; Metallurgy 10 Active

Source: USPTO / EPO open patent data. Inventor disambiguation is heuristic; counts are objective bibliographic measures.