Method of inhibiting HIV replication with 2',3'-dideoxyadenosine

US5616566A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Hiroaki Mitsuya · Rockville, US
• Samuel Broder · Weston, US
• Robert Yarchoan · Bethesda, US

Key dates

• Filing date: Apr 30, 1993
• Grant date: Apr 1, 1997
• Expiry date: Apr 30, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/70
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for inhibiting intracellular replication of HIV in an HIV-infected individual comprising contacting the HIV reverse transcriptase in the HIV-infected cells with 2',3'-dideoxyadenosine-5'-triphosphate whose source is 2',3'-dideoxyadenosine or a pharmaceutically acceptable salt or prodrug thereof.