Patent · US Expired

Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling

US5618704A · kind A · utility

474Cited by
2References
10Claims
0Family size

Assignee

Inventors

Key dates

Filing dateSep 2, 1994
Grant dateApr 8, 1997
Priority date—
Expiry dateSep 2, 2014

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07H21/00
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

Methods for preparing oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. In preferred embodiments, the methods involve radical coupling of 3'- and 5'-substituted or 5'- and 3'-substituted nucleosidic synthons.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.