Antibodies to cardiac hypertrophy factor and uses thereof

US5624806A · kind A · utility

Assignees

• Genentech, Inc. · US
• The Regents of the University of California · US

Inventors

• Joffre B. Baker · Montara, US
• Kenneth R. Chien · Cambridge, US
• Kathleen King · Pacifica, US
• Diane Pennica · Burlingame, US
• William I. Wood · Hillsborough, US

Key dates

• Filing date: May 17, 1995
• Grant date: Apr 29, 1997
• Expiry date: May 17, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Isolated CHF, isolated DNA encoding cardiac hypertrophy factor (CHF), and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.