Hybridomas producing antibodies to cardiac hypertrophy factor

US5627073A · kind A · utility

Assignees

• Genentech, Inc. · US
• The Regents of the University of California · US

Inventors

• Joffre B. Baker · Montara, US
• Kenneth R. Chien · Cambridge, US
• Kathleen King · Pacifica, US
• Diane Pennica · Burlingame, US
• William I. Wood · Hillsborough, US

Key dates

• Filing date: May 17, 1995
• Grant date: May 6, 1997
• Expiry date: May 17, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Isolated CHF (also referred to cardiac hypertrophy factor or cardiotrophin-1), isolated DNA encoding CHF, hybridomas and cell lines producing antibodies to CHF, and recombinant or synthetic methods of preparing CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.