3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission

US5629325A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• Nan-Horng Lin · Mundelein, US
• Yun He · Zion, US
• Mark W. Holladay · San Diego, US
• Keith B. Ryther · Round Lake Park, US
• Yihong Li · Millbrae, US

Key dates

• Filing date: Jun 6, 1996
• Grant date: May 13, 1997
• Expiry date: Jun 6, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 3-pyridyloxymethyl heterocyclic ether compounds of the formula: ##STR1## or the pharmaceutically-acceptable salts or prodrugs thereof are selective and potent ligands at neuronal nicotinic cholinergic channel receptors, and are effective in controlling synaptic transmission.