Conformationally locked nucleoside analogues

US5629454A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Victor E. Marquez · Gaithersburg, US
• Juan B. Rodriguez · Dieciséis de Julio, AR
• Marc C. Nicklaus · Elkridge, US
• Joseph J. Barchi, Jr. · Frederick, US
• Maqbool A. Siddiqui · Rockville, US

Key dates

• Filing date: Sep 23, 1994
• Grant date: May 13, 1997
• Expiry date: Sep 23, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H21/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Conformationally locked 4',6'-cyclopropane-fused carbocyclic nucleoside analogues. The compounds are prepared by condensing a cyclopropane-fused carbocyclic allylic alcohol with substituted purine or pyrimidine bases. The condensation products are then modified to produce the adenosine, guanosine, cytidine, thymidine and uracil nucleoside analogues. The compounds are therapeutically useful as antimetabolites, or in the preparation of anti-metabolic agents.