Oligonucleotide analogs capable of passive cell membrane permeation
US5633360A · kind A · utility
503Cited by
3References
12Claims
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Key dates
| Filing date | Apr 14, 1992 |
| Grant date | May 27, 1997 |
| Priority date | — |
| Expiry date | Apr 14, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Oligonucleotides that are capable of passive diffusion across cell membranes are disclosed. These oligonucleotides contain at least two nucleotide residues and show a log distribution coefficient in octanol:water of about 0.0-2.5 and a solubility in water of at least 0.001 .mu.g/mL. In preferred embodiments, either at least 80% of the internucleotide linkages are non-ionic, or at least 80% of the bases contain lipophilic hydrocarbyl substitutions, or a combination of these sums to 80%. These oligonucleotides may be conjugated to label and used to visualize cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.