Protein tyrosine kinase agonist antibodies
US5635177A · kind A · utility
48Cited by
0References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 4, 1994 |
| Grant date | Jun 3, 1997 |
| Priority date | — |
| Expiry date | Apr 4, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Agonist antibodies are disclosed which bind to the extracellular domain of receptor protein tyrosine kinases pTKs, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibodies are useful for activating their respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.