Compounds having phosphorodithioate linkages of high chiral purity
US5635488A · kind A · utility
57Cited by
14References
8Claims
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Key dates
| Filing date | Jun 6, 1995 |
| Grant date | Jun 3, 1997 |
| Priority date | — |
| Expiry date | Jun 6, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3533
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Sequence-specific phosphorothioate oligonucleotides comprising nucleoside units which are joined together by either substantially all Sp or substantially all Rp phosphorothioate intersugar linkages are provided. Such sequence-specific phosphorothioate oligonucleotides having substantially chirally pure intersugar linkages are prepared by enzymatic or chemical synthesis. Sequence-specific phosphorodithioate oligonucleotides are also provided. Such sequence-specific phosphorodithioate oligonucleotides are prepared by chemical synthesis. They are especially well suited as diagnostics, therapeutics and research reagents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.