Benzimidazole derivatives as angiotensin II receptor antagonists, pharmacticals, and treatment of hypertension therewith

US5635525A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Holger Heitsch · Hofheim, DE
• Adalbert Wagner · Gersthofen, DE
• Heinz-Werner Kleemann · Bischofsheim, DE
• Hermann Gerhards · Hofheim, DE
• Bernward Scholkens · Kelkheim, DE

Key dates

• Filing date: Jun 5, 1995
• Grant date: Jun 3, 1997
• Expiry date: Jun 5, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of the formula ##STR1## in which the symbols have the following meaning: X is a monocyclic radical having 3, 4 or 5 ring atoms, PA0 R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.12 and R.sup.13 are, for example, an alkyl radical, PA0 q is zero or 1, PA0 L is, for example, a methylene group and PA0 A is the radical, for example, of a heterocycle are highly active as antagonists of angiotensin II receptors. They can be used as pharmaceuticals or diagnostics.