HIV protease gene and method for its expression

US5637488A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• John Medabalimi · Bethesda, US
• Stephen Oroszlan · Potomac, US
• Peter Mora · Bethesda, US

Key dates

• Filing date: Mar 2, 1993
• Grant date: Jun 10, 1997
• Expiry date: Mar 2, 2013

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/221
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention is a synthetic DNA sequence for encoding a specific enzyme or protease. The protease is essential for the completion (replication) of an infective human immunodeficiency virus (HIV). The invented gene is desirable for the expression of the protease by recombinant methodology in prokaryotic and/or eukaryotic cells and the production of a commercially desirable amount of the protease for biochemical and physical characterization, necessary to find effective inhibitor of the protease, and thereby to block the production of infectious human immunodeficiency virus (HIVs).