Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof

US5639761A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Guido Francois · Oostende, BE
• Gerhard Bringmann · Würzburg, DE
• J. David Phillipson · Cranbrook, GB
• Michael R. Boyd · Mobile, US
• Laurent Aké Assi · Abidjan, CI
• Christoph Schneider · Würzburg, DE
• Georges Timperman · Wilrijk, BE

Key dates

• Filing date: Feb 14, 1994
• Grant date: Jun 17, 1997
• Expiry date: Feb 14, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides antimalarial pharmaceutical compositions containing antimalarial naphthylisoquinoline alkaloids or antimalarial derivatives thereof, useful new antimalarial naphthylisoquinoline alkaloid derivatives, methods for obtaining such derivatives, and methods of using such antimalarial compounds for the prevention of malaria infections in mammals and for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.