Condensed diazepinones, processes for preparing them and agents containing these compounds for treating diseases of the central nervous system and for promoting cerebral blood circulation

US5641772A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Wolfgang Eberlein · Biberach, DE
• Gerhard Mihm · Biberach, DE
• Wolfhard Engel
• Klaus Rudolf · Warthausen, DE
• Henri Doods · Warthausen, DE
• Harald Ziegler
• Michael Entzeroth · Warthausen, DE

Key dates

• Filing date: Apr 13, 1995
• Grant date: Jun 24, 1997
• Expiry date: Apr 13, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New condensed diazepinones of general formula I ##STR1## wherein B represents one of the divalent groups ##STR2## and X, l, m, n and R.sup.1 to R.sup.7 are as defined herein, as well as the salts thereof with inorganic or organic acids and processes for preparing them. These compounds are useful for improving or normalising arteriosclerotically induced disorders of cerebral blood flow, for treating diseases of the central nervous system, particularly Alzheimer's disease and Parkinson's disease, and as vagal pacemakers for treating bradycardia and bradyarrhythmia, and also for improving memory performance.