Low pH hydrophobic interaction chromatography for antibody purification
US5641870A · kind A · utility
564Cited by
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16Claims
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Key dates
| Filing date | Apr 20, 1995 |
| Grant date | Jun 24, 1997 |
| Priority date | — |
| Expiry date | Apr 20, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/803
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for purifying an antibody is provided. In this process, a mixture containing the antibody and contaminant is subjected to low pH hydrophobic interaction chromatography (LPHIC) optionally at low salt concentration. The antibody is eluted from the column in the fraction which does not bind thereto. This process can be preceded and followed by other purification steps.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.