Penam derivatives
US5644053A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 16, 1995 |
| Grant date | Jul 1, 1997 |
| Priority date | — |
| Expiry date | Nov 16, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses compounds having the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is --COR.sup.4, --CN, --CH.sub.2 R.sup.5, halogen, --CH.dbd.CHR.sup.6 or Q and the other is hydrogen or lower alkyl or both R.sup.1 and R.sup.2 together form a .gamma.-lactam ring, PA1 R.sup.3 is hydrogen, lower alkyl, aryl-alkyl, allyl or a residue which is cleavable in vivo, PA1 R.sup.4 is hydrogen, lower alkyl, lower alkoxy, benzyloxy, amino, lower alkylamino or lower alkyl-lower alkoxyamino, PA1 R.sup.5 is hydroxy, --OCONHR.sup.7, --OCONH.sub.2 or a five- or six-membered hetero-aromatic ring which contains N,S and/or O and which is linked via a nitrogen atom, PA1 R.sup.6 is --CN or CHO, PA1 R.sup.7 is --COCH.sub.2 Cl, PA1 Q is a five- or six-membered hetero-aromatic ring which contains N, S and/or O and PA1 n is 0, 1 or 2, and the pharmaceutically compatible salts thereof. These compounds are good .beta.-lactamase inhibitors. They can be used for the prevention or treatment of bacterial infections, optionally together with a .beta.-lactam antibiotic.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.