Methods for treating adenosine kinase related conditions

US5646128A · kind A · utility

Assignee

• Gensia, Inc. · US

Inventors

• Gary Firestein · Del Mar, US
• Bheemarao G. Ugarkar · Escondido, US
• Leonard P. Miller · Homer, US
• Harry E. Gruber · Rancho Santa Fe, US
• David A. Bullough · San Diego, US
• Mark D. Erion · Del Mar, US
• Angelo Castellino · San Diego, US
• Clinton E. Browne · Oceanside, US

Key dates

• Filing date: Dec 1, 1994
• Grant date: Jul 8, 1997
• Expiry date: Dec 1, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/052
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel compounds which selectively inhibit adenosine kinase and methods of preparing adenosine kinase inhibitors are provided. Also provided are methods of treating various inflammatory conditions, including arthritis and SIRS, which may be ameliorated by increased local concentrations of adenosine using adenosine kinase inhibitors.