Primers targeted to CYP2D6 gene for detecting poor metabolizers of drugs
US5648482A · kind A · utility
25Cited by
3References
5Claims
0Family size
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Key dates
| Filing date | Mar 2, 1994 |
| Grant date | Jul 15, 1997 |
| Priority date | — |
| Expiry date | Mar 2, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/106
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for the detection of poor metabolizers of drugs using PCR technology is described comprising a) optionally amplifying a gene coding for an enzyme known to be responsible for the metabolization of drugs, thereby separating it from possible closely related pseudogens, b) amplifying different allelic forms of the gene of step a) and c) detecting the product of step b). Primers for amplification of the genes responsible for the debrisoquine or acetylation phenotype are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.