Method for making intermediates useful in the synthesis of retroviral protease inhibitors
US5648511A · kind A · utility
19Cited by
15References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 25, 1995 |
| Grant date | Jul 15, 1997 |
| Priority date | — |
| Expiry date | May 25, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide or cyanohydrin from a chiral alpha amino aldehyde.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.