Use of nitric oxide releasing compounds as hypoxic cell radiation sensitizers
US5650442A · kind A · utility
77Cited by
5References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 7, 1994 |
| Grant date | Jul 22, 1997 |
| Priority date | — |
| Expiry date | Oct 7, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K41/0038
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen. Also provided are methods of protecting noncancerous cells or tissues in a mammal from radiation, sensitizing cancerous cells in a mammal to chemotherapeutic agents, and protecting noncancerous cells or tissues in a mammal from chemotherapeutic agents, all by administration of the same compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.