Nitric oxide-releasing polymers to treat restenosis and related disorders

US5650447A · kind A · utility

Assignees

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US
• Comedicus Incorporated · US

Inventors

• Larry K. Keefer · Bethesda, US
• Thomas C. Hutsell · North Oaks, US

Key dates

• Filing date: Mar 17, 1994
• Grant date: Jul 22, 1997
• Expiry date: Mar 17, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F8/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of amelioration, treatment and prevention for restenosis and related disorders are provided. Methods involve the administration of nitric oxide by a nitric oxide delivery means comprising a restenosis-ameliorating or therapeutically/prophylactically effective amount of either a polymer to which is bound a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group a compound comprising a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group. Also provided are nitric oxide delivery means comprising such nitric oxide-releasing polymers or compounds for use in such methods. Preferably, the delivery means is coated with a nitric oxide-releasing polymer, which may be biodegradable, and enables the controllable and predictable release of NO to a given site in such a manner that effective ameliorating, prophylactic or therapeutic dosing is realized.