Patent · US Expired

Peptide plasminogen activators

US5656269A · kind A · utility

5Cited by

7References

14Claims

0Family size

Assignees

Chiron Corporation · US
Behringwerke Aktiengesellschaft · DE

Inventors

Nancy L. Haigwood · Oakland, US
Guy Mullenbach · Oakland, US
Ernst-Guenter Afting · Marburg, DE
Eric-Paul Paques · Marburg, DE

Key dates

Filing date	Jan 31, 1995
Grant date	Aug 12, 1997
Priority date	—
Expiry date	Jan 31, 2015

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y304/21069
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Novel polypeptide compositions based on the amino acid sequence of tissue plasminogen activator (tPA) are provided having improved properties over natural tissue plasminogen activator. Particularly, reduced fibrin stimulation of plasminogenolytic activity and/or enhanced affinity to fibrin surfaces are provided by modifying the C-terminus by deletions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.