Nucleotide analogs
US5656745A · kind A · utility
68Cited by
5References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 17, 1993 |
| Grant date | Aug 12, 1997 |
| Priority date | — |
| Expiry date | Sep 17, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.