Succinimide and maleimide cytokine inhibitors
US5658940A · kind A · utility
61Cited by
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18Claims
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Key dates
| Filing date | Oct 6, 1995 |
| Grant date | Aug 19, 1997 |
| Priority date | — |
| Expiry date | Oct 6, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/48
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel succinimides and maleimides are inhibitors of tumor necrosis factor .alpha. and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. A typical embodiment is methyl 3-(3',4',5',6'-tetrahydrophthalimido)-3-(3",4"-dimethoxyphenyl)propionate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.