High affinity nucleic acid ligands containing modified nucleotides
US5660985A · kind A · utility
219Cited by
4References
10Claims
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Key dates
| Filing date | Apr 27, 1995 |
| Grant date | Aug 26, 1997 |
| Priority date | — |
| Expiry date | Apr 27, 2015 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/976
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Nucleic acid ligands containing modified nucleotides are described as are methods for producing such oligonucleotides. Such ligands enrich the chemical diversity of the candidate mixture for the SELEX process. Specific examples are provided of nucleic acids containing nucleotides modified at the 2'- and 5-position. Specific 2-OH and 2'-NH.sub.2 modified RNA ligands to thrombin are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.