Treatment of congestive heart failure
US5661122A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 2, 1994 |
| Grant date | Aug 26, 1997 |
| Priority date | — |
| Expiry date | Aug 2, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of enhancing myocardial contractility and cardiac performance in a mammal with congestive heart failure are disclosed. In a first method a mammal with congestive heart failure is treated by administering to the mammal an effective amount of a combination of growth hormone (GH) and insulin-like growth factor (IGF-I). A second method comprises administering to the mammal an effective amount of a combination of GH and IGF-I in the presence of an ACE inhibitor. This method results in enhancement of myocardial contractility and cardiac performance above the level achieved with ACE inhibition alone. Preferably the mammal is a human.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.