Assay using recombinant histidyl-tRNA synthetase

US5663066A · kind A · utility

Assignees

• The United States of America, as represented by the Department of Health and Human Services · US
• National Institutes of Health, Office of Technology Transfer · US

Inventors

• Nina Raben · Rockville, US
• Ralph A. Nichols · Lee Vining, US
• Paul Plotz · Washington, US
• Richard Leff · Charleston, US

Key dates

• Filing date: Jun 7, 1995
• Grant date: Sep 2, 1997
• Expiry date: Jun 7, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/811
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Recombinant Histidyl tRNA synthetase produced by non-mammalian host cells is used in a sensitive assay to determine the presence of autoimmune diseases in mammals. Methods for isolating, cloning and expressing rHRS are described. In addition, a kit for determining the presence of an autoimmune disease is provided.