Method and compositions for making ACSF and ACSF antagonists
US5668106A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jan 4, 1994 |
| Grant date | Sep 16, 1997 |
| Priority date | — |
| Expiry date | Jan 4, 2014 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The complete amino acid and nucleotide sequence for adenylate cyclase stimulating factor is provided, thereby facilitating the synthesis of ACSF in recombinant cell culture. ACSF amino acid sequence variants and ACSF antibodies are provided which are useful in the treatment of humoral hypercalcemia of malignancy or in immunoassays for ACSF. In particular, antibodies capable of binding only the C-terminal domains of ACSF are useful in immunoassays for ACSF which avoid interference by parathyroid hormone. Also provided are novel polypeptides selected from the group of the ACSF basic peptide, the ACSF C-terminal peptide, or the ACSF domain containing both of the basic and C-terminal peptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.