Isothiazolones lower plasma levels of lipoprotein(a)

US5668162A · kind A · utility

Inventors

• John Michael Domagala · Canton, US
• Helen Tsenwhei Lee · Ann Arbor, US
• Randy Ranjee Ramharack · Ann Arbor, US
• Bruce D. Roth · Ann Arbor, US
• Tomi Sawyer · Ann Arbor, US
• Drago R. Sliskovic · Ypsilanti, US

Key dates

• Filing date: May 7, 1996
• Grant date: Sep 16, 1997
• Expiry date: May 7, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Plasma levels of Lp(a) are lowered by administering an isothiazolone having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het.