Method of cleaving DNA

US5672490A · kind A · utility

Assignee

• University of Texas, Board of Regents · US

Inventors

• Jonathan L. Sessler · Austin, US
• Brent L. Iverson · Austin, US
• Vladimir Kral · Austin, US
• Kevin Shreder · Austin, US
• Hiroyuki Furuta · Ooita, JP
• Richard E. Thomas · Old Bridge, US

Key dates

• Filing date: Jun 2, 1995
• Grant date: Sep 30, 1997
• Expiry date: Jun 2, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/101
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides various novel covalently modified sapphyrin derivatives and conjugates; polymers including sapphyrin or derivatives thereof; and chromatographic supports including sapphyrins and other expanded porphyrins and derivatives thereof. Disclosed are water soluble sapphyrins, including polyhydroxysapphyrins and sapphyrin-sugar derivatives; sapphyrin-metal chelating conjugates; sapphyrin nucleobase conjugates; oligosapphyrins and polysapphyrins, including sapphyrin dimers, trimers, oligomers and higher polymers; and polymer supported expanded porphyrin compositions, including advantageous rubyrin- and sapphyrin-based chromatography columns and electrophoretic supports. Sapphyrin oligomers and polymers and polymer supported expanded porphyrins, such as, e.g., glass and silica expanded porphyrin constructs, are disclosed which include both repeating units of sapphyrin derivatives alone and which include other units, for example, nucleobases, sapphyrin-nucleobase conjugates and long chain alkyl groups.