Method of preventing or treating disease characterized by neoplastic cells expressing CD40

US5674492A · kind A · utility

Assignees

• IMMUNEX CORPORATION · US
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Richard J. Armitage · Bainbridge Island, US
• William C. Fanslow, III · Federal Way, US
• Dan L. Longo · Kensington, US
• William Murphy · Reno, US

Key dates

• Filing date: Dec 21, 1994
• Grant date: Oct 7, 1997
• Expiry date: Dec 21, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/73
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There is disclosed a method of treating a mammal afflicted with a disease characterized by neoplastic cells that express CD40, comprising administering a therapeutically effective amount of a CD40 binding protein in a pharmaceutically acceptable buffer. CD40 binding proteins include monoclonal antibodies to CD40, and CD40 ligand. CD40 binding proteins may also be used to prevent disease characterized by neoplastic cells that express CD40, in individuals at risk for such disease.