Papillomaviral expression inhibitors

US5674835A · kind A · utility

Assignees

• New England Medical Center Hospitals. Inc. · US
• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Elliot J. Androphy · Natick, US
• Douglas R. Lowy · Washington, US
• John T. Schiller · Silver Spring, US

Key dates

• Filing date: Jun 6, 1995
• Grant date: Oct 7, 1997
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/20022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of inhibiting the growth of a virus, the DNA of the virus including the nucleic acid sequence 5' ACCXNNNPyCGGTXY3', wherein each N, X, and Y is, independently, any nucleotide, and Py is C or T, the nucleic acid sequence being capable of binding to a protein encoded by the DNA of the virus, the protein, upon binding to the nucleic acid sequence, being capable of causing the enhancement of the transcription of DNA of the virus, the method including inhibiting the protein from binding to the nucleic acid sequence to repress the transcription of DNA of said virus to inhibit the growth of the virus.