Polynucleotides encoding the anti-PEM antibody BW835 variable domains and expression vectors

US5674994A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Klaus Bosslet · Marburg, DE
• Peter Pfleiderer · Marburg, DE
• Gerhard Seemann · Lahntal, DE

Key dates

• Filing date: Jun 6, 1995
• Grant date: Oct 7, 1997
• Expiry date: Jun 6, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to polynucleotides encoding the BW 835 variable domain of an antibody against a tumor-associated antigen which is mainly derived from tumors from the group of carcinomas of the breast, ovaries and prostate, as well as adenocarcinomas of the lung, which additionally react with polymorphic epithelial mucin (PEM), and expression vectors containing the polynucleotides.