Heteroatomic oligonucleoside linkages
US5677437A · kind A · utility
501Cited by
4References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 23, 1995 |
| Grant date | Oct 14, 1997 |
| Priority date | — |
| Expiry date | Feb 23, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Oligonucleotide-mimicking macromolecules that have improved nuclease resistance are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in natural oligonucleotides with four atom linking groups provide unique compounds that are useful in regulating RNA expression and in therapeutics. Methods of synthesis and use also are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.