DNA encoding N- and C- terminally truncated colony stimulating factor-1 variants

US5681719A · kind A · utility

Assignee

• Chiron Corporation · US

Inventors

• Martha B. Ladner · Oakland, US
• Janelle A. Noble · Berkeley, US
• George A. Martin · Berkeley, US
• Ernest S. Kawasaki · Modesto, US
• Mazie Yee Coyne · Danville, US
• Robert F. Halenbeck · San Rafael, US
• Kirston E. Koths · Corona, US

Key dates

• Filing date: Mar 8, 1995
• Grant date: Oct 28, 1997
• Expiry date: Mar 8, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/145
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

DNA for new forms of CSF-1 are provided which relate to N-terminal and C-terminal truncations. Specifically, N-.gradient.3 terminal truncations of the short and long forms of CSF-1 have been found to be particularly advantageous. These forms may have a C-terminal truncation at a variety of different amino acids beyond position 149.